161546685 PVC Union Globe Valve Industrial Water Treatment Corrosion-Resistant 150PSI Manual Valve

1. Pharmaceutical-Grade Flow Measurement Solution​

The GF Signet 161546685 Proline is an ultra-hygienic magnetic flow transmitter engineered for aseptic processing in biopharmaceutical and vaccine manufacturing. Featuring ​full-bore PFA lining​ and ​platinum-iridium electrodes, this device delivers ​​±0.15% accuracy​ across ​0.01–12 m/s flow velocities​ with ​​≤50ms response time. Its ​IP69K-rated 316L stainless steel housing​ withstands ​150°C SIP cycles​ and ​100-bar CIP cleaning. The "6685" suffix denotes ​4-20mA + WirelessHART outputs, ​DN80 tri-clamp connection, and ​SIL 3 compliance​ per IEC 61508. Certified for ​​-40°C to +150°C operation, it incorporates ​FDA-compliant material traceability​ and ​EHEDG Type EL Class I certification​ with ​Ra≤0.4µm surface finish​ per ASME BPE-2022. Designed for single-use bioreactors, vaccine filling lines, and advanced therapy medicinal products (ATMPs), this transmitter enables ​electrode integrity monitoring, ​bidirectional flow totalization, and ​predictive maintenance alerts​ via digital communication. Integrated ​auto-electrode cleaning​ maintains accuracy in proteinaceous solutions while ​empty pipe detection​ ensures fail-safe operation.

​2. Critical Technical Specifications​

This transmitter operates with ​10–36V DC power​ (≤5W consumption) and features ​DN80 process connection​ with ​ISO 2852 tri-clamps. Key parameters include ​0.001 m/s resolution, ​​±0.1% repeatability, and ​3μS/cm minimum conductivity. Electrical isolation reaches ​2,500V AC​ with ​8kV surge protection. Materials: ​PFA liner​ (FDA 21 CFR 177.1550), ​Pt/Ir electrodes, ​FFKM seals, and ​electropolished 316L SS body. Environmental ratings: ​IP69K/NEMA 6P, ​20g shock resistance​ (IEC 60068-2-27), ​5g vibration immunity​ (10–500Hz). Accuracy maintains ​​±0.15% of rate​ at 20°C with ​​<±0.03%/°C drift. Process connection: ​Self-draining 3° slope design​ with ​diamond-polished weld seams. Certifications: ​EHEDG Type EL Class I, ​3-A 74-03, ​FDA 21 CFR 177.2600, ​ATEX Zone 1/21, ​SIL 3 (PFHD 1×10⁻⁹/h)​. Dimensions: ​250×200×110mm​ with ​25-year MTBF​ at 80°C.

​3. Aseptic Bioprocessing Applications​

This transmitter excels in mission-critical applications including ​perfusion bioreactor media flow control​ (0.1–10 L/min), ​vaccine filling line volume verification​ (±0.25mL accuracy), and ​monoclonal antibody harvest transfer. Critical implementations extend to ​cell therapy product transfer, ​WFI distribution monitoring, ​viral vector purification, and ​sterile ointment filling. It solves precision challenges in ​continuous bioprocessing skids​ requiring ≤1% accuracy for PAT compliance and ​single-use systems​ where conventional sensors introduce contamination risks. The DN80 tri-clamp connections enable rapid changeover between campaigns while SIP compatibility supports steam-through sterilization without disassembly. WirelessHART capability facilitates installation in isolators and restricted access areas where cabling is impractical. SIL 3 certification ensures reliable overfill prevention in GMP-critical vessels with PFHD rates meeting ISA 84.00.01 requirements for safety instrumented systems.

​4. Functional Advantages​

• ​Aseptic Design Integrity:
  EHEDG-certified crevice-free flow path (Ra≤0.4µm)
  Diamond-polished welds (Ra≤0.1µm) prevent biofilm adhesion
• ​Measurement Precision:
  Auto-flow profile compensation (±0.05% velocity error)
  Adaptive noise rejection for bubble/particle interference
• ​Diagnostic Intelligence:
  Real-time electrode coating monitoring (0.005mm resolution)
  Liner integrity checking via capacitance tomography
• ​Validation Support:
  Automated as-built reports per GAMP 5 Annex 11
  Electronic audit trail (21 CFR Part 11 compliant)
• ​Sterilization Resilience:
  100,000+ SIP cycle capability at 150°C
  CIP compatibility with PAA/NaOH/HNO₃ at pH 0–14
• ​Lifecycle Durability:

  25-year electrode lifespan
  10-year calibration stability with drift compensation

​5. Smart Operation & Pharma 4.0 Integration​

​Measurement Principle​ utilizes ​Faraday's Law​ where conductive fluid flow generates voltage proportional to velocity through an electromagnetic field. ​WirelessHART Diagnostics​ provide continuous monitoring of ​electrode integrity index​ (0–100%), ​liner wear rate​ (µm/year), and ​process noise signature. Predictive maintenance features include ​coating accumulation alerts​ triggering automatic cleaning cycles at >0.03mm buildup and ​flow profile anomaly detection​ identifying pipe obstructions via turbulence analysis. Safety functions incorporate ​SIL 3-certified overfill prevention​ with independent trip circuit and ​fail-safe state​ forcing 22mA output during faults. Pharma 4.0 integration enables ​MQTT data streaming​ to MES systems, ​OPC UA asset management, and ​digital twin synchronization​ for predictive process optimization. Compliance tools generate ​SEMI E142 formatted data​ for continuous process verification and ​automated IQ/OQ documentation​ with NIST-traceable calibration records.

Packaging & Shipping

Company Information
Xiamen ZhiCheng Automation Technology Co., Ltdit is a leading global supplier of control system components. We specialize in control systems and drives.

With many years of experience in the industrial sector, we consistently deliver the highest quality of spare parts.which make sure that all this jobs are

perfectly.

we are major in PLC,Sensors,HIM,Transmitters.

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